TGF-beta Signaling in Human Breast Cancer Cells

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Title: TGF-beta Signaling in Human Breast Cancer Cells
Description: Active TGF-beta (green) and latency-associated factor (red) in human breast cancer cells (nuclei, blue). TGF-beta is a pleiotropic signaling molecule found in the extracellular environment of cells that helps suppress tumors and promotes cancer metastasis. TGF-beta is typically found in an inactive form where the active TGF-beta is bound to latency-associated peptide (LAP). Only after dissociation of LAP from TGF-beta can cells sense active TGF-beta. This image measures signaling by TGF-beta in a human breast cancer cell line.

This image was originally submitted as part of the 2015 NCI Cancer Close Up project.

This image is part of the NCI Cancer Close Up 2015 collection.

See also https://visualsonline.cancer.gov/closeup.
Topics/Categories: Cancer Types -- Breast Cancer
Cells or Tissue -- Abnormal Cells or Tissue
Type: Color, Photo
Source: NCI Center for Cancer Research
Creator: Christina Stuelten and Anita Roberts
Date Created: June 2005
Date Added: April 9, 2015
Reuse Restrictions: None - This image is in the public domain and can be freely reused. Please credit the source and, where possible, the creator listed above.