TGF-beta Signaling in Human Breast Cancer Cells
|TGF-beta Signaling in Human Breast Cancer Cells
Active TGF-beta (green) and latency-associated factor (red) in human breast cancer cells (nuclei, blue). TGF-beta is a pleiotropic signaling molecule found in the extracellular environment of cells that helps suppress tumors and promotes cancer metastasis. TGF-beta is typically found in an inactive form where the active TGF-beta is bound to latency-associated peptide (LAP). Only after dissociation of LAP from TGF-beta can cells sense active TGF-beta. This image measures signaling by TGF-beta in a human breast cancer cell line.
This image was originally submitted as part of the 2015 NCI Cancer Close Up project.
Cancer Types -- Breast Cancer
Cells or Tissue -- Abnormal Cells or Tissue
|Color, Photo (JPEG format)
|NCI Center for Cancer Research
|Christina Stuelten and Anita Roberts
|April 9, 2015
|None - This image is in the public domain and can be freely reused. Please credit the source and, where possible, the creator listed above.