Ciliary Pocket Membrane

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Title: Ciliary Pocket Membrane
Description: Understanding the mechanisms regulating transport of signaling molecules to and from the cilia is important for developing drugs targeted against ciliary-associated cancer pathways. The ciliary membrane is continuous with the plasma membrane through a specialized pocket-like membrane referred to as the ciliary pocket. Here, structured illumination microscopy (SIM) imaging of RPE cells shows the ciliary membrane and ciliary pocket. The membrane reshaping protein EHD1 (green) specifically accumulates at the ciliary pocket membrane while the Hedgehog pathways receptor Smoothened localizes to the ciliary membrane (red). The base of the cilia is marked by the mother centriole distal appendage protein CEP164 (pink) and nuclei (blue).

This image was originally submitted as part of the 2015 NCI Cancer Close Up project.

This image is part of the NCI Cancer Close Up 2015 collection.

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Topics/Categories: Cells or Tissue -- Normal Cells or Tissue
Type: Color, Photo
Source: NCI Center for Cancer Research
Creator: Quanlong Lu, Christopher Westlake
Date Created: 2014
Date Added: April 9, 2015
Reuse Restrictions: None - This image is in the public domain and can be freely reused. Please credit the source and, where possible, the creator listed above.