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The patient is a 53 year old woman with metastatic melanoma to multiple subcutaneous sites and retroperitoneum. She was treated with tumor infiltrating lymphocytes (TILs) transduced with the gene for tumor necrosis factor (TNF). Pretreatment biopsy shows multiple live melanoma cells with little lymphoid infiltrate. Following treatment with TNF gene modified TILs plus interleukin-2, a biopsy of another lesion showed massive coagulative necrosis of the tumor with no viable tumor seen. This is a typical picture seen in experimental animals treated with tumor necrosis factor. This patient has had a substantial objective response that is currently ongoing at nine months following initiation of treatment.
For additional resource, see the following web site:
See also http://www.cancer.gov/cancertopics/wyntk/melanoma.
Cancer Types -- Melanoma
Treatment -- Experimental Therapy
|Source:||Dr. Steven Rosenberg|
|Date Added:||January 1, 2001|
|Reuse Restrictions:||None - This image is in the public domain and can be freely reused. Please credit the source and, where possible, the creator listed above.|