Metastasis Illustration

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Title: Metastasis Illustration
Description: The metastatic colony is the end result of a complicated multistep process. The tumor cells from a primary tumor invade local tissue and gain access to the venous circulation (intravasation). Circulating tumor cells, singly or in clumps, are transported to target organs where they lodge in the capillary bed. Thus arrested, these tumor cells penetrate the endothelial cell lining and the underlining basement membrane to exit the circulation (extravasation). They then grow as a metastatic colony, a development that requires new blood vessels (neovascularization). To complete this multistep process, the tumor cells must overcome the host's defenses.
Topics/Categories: Cells or Tissue -- Abnormal Cells or Tissue
Type: Color, Illustration
Source: National Cancer Institute
Creator: Unknown Illustration
AV Number: AV-8805-3460
Date Created: May 1988
Date Added: January 1, 2001
Reuse Restrictions: None - This image is in the public domain and can be freely reused. Please credit the source and, where possible, the creator listed above.