Ultra-Thermostable RNA Nanoparticles for Solubilizing and High-Yield Loading of Paclitaxel for Breast Cancer Therapy
| Title: | Ultra-Thermostable RNA Nanoparticles for Solubilizing and High-Yield Loading of Paclitaxel for Breast Cancer Therapy |
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| Description: |
Cryo-electron microscopy (EM) image of RNA four-way junction (4WJ) nanoparticles (NPs) conjugated with paclitaxel (PTX) binding to cells shown by confocal microscopy. Top left image shows motion-corrected cryo-EM micrograph of 4WJ-X-24 PTXs NPs, while bottom images show in vitro cell binding of 4WJ-X-24 PTXs-EGFRapt NPs, shown by confocal microscopy (blue: nucleus; green: cytoskeleton; red: RNA NPs). This NP complex is shown to exhibit ultra-thermodynamic stability to solubilize and load paclitaxel for targeted cancer therapy. Source: Guo S, Vieweger M, Zhang K, Yin H, Wang H, Li X, Li S, Hu S, Sparreboom A, Evers BM, Dong Y, Chiu W, Guo P. Ultra-thermostable RNA nanoparticles for solubilizing and high-yield loading of paclitaxel for breast cancer therapy. Nat Commun. 2020 Feb 20;11(1):972. doi: 10.1038/s41467-020-14780-5. PMID: 32080195; PMCID: PMC7033104. See also pubmed.ncbi.nlm.nih.gov/32080195/. |
| Topics/Categories: | Science and Technology -- Nanotechnology |
| Type: | Color, Photo (JPEG format) |
| Source: | National Cancer Institute (NCI) |
| Date Created: | Unknown |
| Date Added: | November 15, 2023 |
| Reuse Restrictions: | None - This image is in the public domain and can be freely reused. Please credit the source and, where possible, the creator listed above. |