Targeting Multivalent Nanosensors to Invasive Colorectal Cancer CRC through Tumor Acidosis
| Title: | Targeting Multivalent Nanosensors to Invasive Colorectal Cancer CRC through Tumor Acidosis |
|---|---|
| Description: |
High-throughput cryo-fluorescence tomography (CFT) on the whole animal after administration of labeled nanosensors and cell-based segmentation analysis of tumor lesions. Zoomed in image shows colocalization of matrix metalloproteinase 9 (MMP9) immunofluorescence (red) and PRISM-labelled acidic areas (green) in tumor lesions of lung sections cell-based segmentation. This system is as a multimodal nanosensor pan-cancer test platform engineered to target tumors through acidosis, respond to proteases in the microenvironment to release urinary reporters and (optionally) carry positron emission tomography (PET) probes for diagnostic imaging. Source: Hao L, Rohani N, Zhao RT, Pulver EM, Mak H, Kelada OJ, Ko H, Fleming HE, Gertler FB, Bhatia SN. Microenvironment-triggered multimodal precision diagnostics. Nat Mater. 2021 Oct;20(10):1440-1448. doi: 10.1038/s41563-021-01042-y. Epub 2021 Jul 15. PMID: 34267368. See also pubmed.ncbi.nlm.nih.gov/34267368/. |
| Topics/Categories: | Science and Technology -- Nanotechnology |
| Type: | Color, Photo (JPEG format) |
| Source: | National Cancer Institute (NCI) |
| Date Created: | Unknown |
| Date Added: | November 15, 2023 |
| Reuse Restrictions: | None - This image is in the public domain and can be freely reused. Please credit the source and, where possible, the creator listed above. |