Mixed-Charge Nanoparticles Targeted Crystallization in Lysosomes to Induce Selective Death of Cancer Cells
|Title:||Mixed-Charge Nanoparticles Targeted Crystallization in Lysosomes to Induce Selective Death of Cancer Cells|
Dark-field microscopy (DFM) images of aggregated mixed-charge nanoparticles (NPS). The NPs are covered with certain ratios of positively and negatively charged ligands that start as small, endocytosis-prone clusters at cell surfaces and develop to large and well-ordered nanoparticle assemblies and crystals inside cancer lysosomes. These NPs can selectively target lysosomes in cancerous cells while exhibiting only marginal cytotoxicity towards normal cells.
Source: Borkowska M, Siek M, Kolygina DV, Sobolev YI, Lach S, Kumar S, Cho YK, Kandere-Grzybowska K, Grzybowski BA. Targeted crystallization of mixed-charge nanoparticles in lysosomes induces selective death of cancer cells. Nat Nanotechnol. 2020 Apr;15(4):331-341. doi: 10.1038/s41565-020-0643-3. Epub 2020 Mar 16. PMID: 32203435.
See also pubmed.ncbi.nlm.nih.gov/32203435/.
|Topics/Categories:||Science and Technology -- Nanotechnology|
|Type:||Color, Photo (JPEG format)|
|Source:||National Cancer Institute (NCI)|
|Date Added:||November 15, 2023|
|Reuse Restrictions:||None - This image is in the public domain and can be freely reused. Please credit the source and, where possible, the creator listed above.|