Mixed-Charge Nanoparticles Targeted Crystallization in Lysosomes to Induce Selective Death of Cancer Cells
| Title: | Mixed-Charge Nanoparticles Targeted Crystallization in Lysosomes to Induce Selective Death of Cancer Cells |
|---|---|
| Description: |
Dark-field microscopy (DFM) images of aggregated mixed-charge nanoparticles (NPS). The NPs are covered with certain ratios of positively and negatively charged ligands that start as small, endocytosis-prone clusters at cell surfaces and develop to large and well-ordered nanoparticle assemblies and crystals inside cancer lysosomes. These NPs can selectively target lysosomes in cancerous cells while exhibiting only marginal cytotoxicity towards normal cells. Source: Borkowska M, Siek M, Kolygina DV, Sobolev YI, Lach S, Kumar S, Cho YK, Kandere-Grzybowska K, Grzybowski BA. Targeted crystallization of mixed-charge nanoparticles in lysosomes induces selective death of cancer cells. Nat Nanotechnol. 2020 Apr;15(4):331-341. doi: 10.1038/s41565-020-0643-3. Epub 2020 Mar 16. PMID: 32203435. See also pubmed.ncbi.nlm.nih.gov/32203435/. |
| Topics/Categories: | Science and Technology -- Nanotechnology |
| Type: | Color, Photo (JPEG format) |
| Source: | National Cancer Institute (NCI) |
| Date Created: | Unknown |
| Date Added: | November 15, 2023 |
| Reuse Restrictions: | None - This image is in the public domain and can be freely reused. Please credit the source and, where possible, the creator listed above. |