Single-Component Photoinducible Nucleolus-Targeting Tools, Designated pNUTs to Enable Rapid and Reversible Nucleoplasm-to-Nucleolus Shuttling
| Title: | Single-Component Photoinducible Nucleolus-Targeting Tools, Designated pNUTs to Enable Rapid and Reversible Nucleoplasm-to-Nucleolus Shuttling |
|---|---|
| Description: |
Confocal images showing specific location of engineered cryptochrome 2 (CRY2)-based photoinducible nucleolus-targeting tools (pNUTs) for light-inducible translocation into nucleolar subcompartments. Upon light illumination, rapid translocation of mCh-pNUT3 was observed into the intranucleolar granular component (GC) region, as evidenced by its tight colocalization with GFP-NPM1 (a GC marker) but not with mEmerald-fibrillarin (a dense fibrillar component (DFC) marker). Source: Tan P, Hong T, Cai X, Li W, Huang Y, He L, Zhou Y. Optical control of protein delivery and partitioning in the nucleolus. Nucleic Acids Res. 2022 Jul 8;50(12):e69. doi: 10.1093/nar/gkac191. PMID: 35325178; PMCID: PMC9262612. See also www.ncbi.nlm.nih.gov/pmc/articles/PMC9262612/. |
| Topics/Categories: | Science and Technology -- Nanotechnology |
| Type: | Color, Photo (JPEG format) |
| Source: | National Cancer Institute (NCI) |
| Date Created: | Unknown |
| Date Added: | November 15, 2023 |
| Reuse Restrictions: | None - This image is in the public domain and can be freely reused. Please credit the source and, where possible, the creator listed above. |