Short Peptide Mimotopes with Enhanced Antitumor Immunogenicity
| Title: | Short Peptide Mimotopes with Enhanced Antitumor Immunogenicity |
|---|---|
| Description: |
Images of mouse lungs stained with Bouin’s solution. The goal was to perform an in vivo screen to identify short peptide enhanced mimotopes (“e-mimotopes”) that could act as therapeutic vaccine antigens. Peptides containing an abbreviated polyhistidine-tag (his-tag) spontaneously formed stable particles with CPQ liposome adjuvant system and induced strong antitumor immune responses with nanogram peptide doses. Mice were inoculated with melanoma tumor cells on day 0 and injected with CPQ liposome adjuvant system with the indicated epitopes (on days 4 and 11. Image of lungs were assessed on day 23. Source: He X, Zhou S, Quinn B, Jahagirdar D, Ortega J, Long MD, Abrams SI, Lovell JF. An In Vivo Screen to Identify Short Peptide Mimotopes with Enhanced Antitumor Immunogenicity. Cancer Immunol Res. 2022 Mar 1;10(3):314-326. doi: 10.1158/2326-6066.CIR-21-0332. PMID: 34992135; PMCID: PMC8898291. See also www.ncbi.nlm.nih.gov/pmc/articles/PMC8898291/. |
| Topics/Categories: | Science and Technology -- Nanotechnology |
| Type: | Color, Photo (JPEG format) |
| Source: | National Cancer Institute (NCI) |
| Date Created: | Unknown |
| Date Added: | November 15, 2023 |
| Reuse Restrictions: | None - This image is in the public domain and can be freely reused. Please credit the source and, where possible, the creator listed above. |