Mitochondria-Targeted, Copper-Depleting Nanoparticle (CDN) against Triple-Negative Breast Cancer (TNBC)

preview Add to My Pictures


Title: Mitochondria-Targeted, Copper-Depleting Nanoparticle (CDN) against Triple-Negative Breast Cancer (TNBC)
Description: Optical images showing a safe, less-toxic, mitochondria-targeted copper-depleting nanoparticle (CDN) taken up by triple-negative breast cancer (TNBC cells) towards intracellular copper depletion followed by apoptosis. Bottom panel shows control CCL-1 bioluminescence imaging depicting intracellular labile copper. Addition of CDN decreased the labile copper concentration as indicated by a lower bioluminescent signal from CCL-1. Extra copper supply rescued the depleting effect, while the copper-starved group with excess EDTA showed the highest CDN fluorescence and the lowest CCL-1 luminescence.

Source: Cui L, Gouw AM, LaGory EL, Guo S, Attarwala N, Tang Y, Qi J, Chen YS, Gao Z, Casey KM, Bazhin AA, Chen M, Hu L, Xie J, Fang M, Zhang C, Zhu Q, Wang Z, Giaccia AJ, Gambhir SS, Zhu W, Felsher DW, Pegram MD, Goun EA, Le A, Rao J. Mitochondrial copper depletion suppresses triple-negative breast cancer in mice. Nat Biotechnol. 2021 Mar;39(3):357-367. doi: 10.1038/s41587-020-0707-9. Epub 2020 Oct 19. PMID: 33077961; PMCID: PMC7956242.

See also
Topics/Categories: Science and Technology -- Nanotechnology
Type: Color, Photo (JPEG format)
Source: National Cancer Institute (NCI)
Date Created: Unknown
Date Added: November 15, 2023
Reuse Restrictions: None - This image is in the public domain and can be freely reused. Please credit the source and, where possible, the creator listed above.