Targeted Nanocarriers that Can Deliver In Vitro-Transcribed Mrna Encoding Bites to Host Myeloid Cells Recruited in the Tumor Microenvironment
|Title:||Targeted Nanocarriers that Can Deliver In Vitro-Transcribed Mrna Encoding Bites to Host Myeloid Cells Recruited in the Tumor Microenvironment|
Confocal microscopy of various healthy tissues isolated from immunocompetent mice and ovarian tumor lesions. Epithelial cell adhesion molecule (EpCAM) is expressed in non-pathological tissue as well as malignant lesions, where ovarian tumor lesions expressed more moderate and heterogeneous levels of EpCAM. Polymeric nanoparticles encoding a murine version of the EpCAM × CD3 bispecific antibody were employed in this study to achieve high gene transfer into circulating myeloid cells, which subsequently secrete Bispecific T-Cell Engagers (BiTEs) and effectively concentrate this drug at tumor sites.
Source: Hao S, Inamdar VV, Sigmund EC, Zhang F, Stephan SB, Watson C, Weaver SJ, Nielsen UB, Stephan MT. BiTE secretion from in situ-pr.ogrammed myeloid cells results in tumor-retained pharmacology. J Control Release. 2022 Feb;342:14-25. doi: 10.1016/j.jconrel.2021.12.029. Epub 2021 Dec 23. PMID: 34953983; PMCID: PMC8840964.
See also www.ncbi.nlm.nih.gov/pmc/articles/PMC8840964/.
|Topics/Categories:||Science and Technology -- Nanotechnology|
|Type:||Color, Photo (JPEG format)|
|Source:||National Cancer Institute (NCI)|
|Date Added:||November 15, 2023|
|Reuse Restrictions:||None - This image is in the public domain and can be freely reused. Please credit the source and, where possible, the creator listed above.|