Immune Checkpoint Inhibitor (CTLA-4)

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Title: Immune Checkpoint Inhibitor (CTLA-4)
Description: Immune checkpoint inhibitor; the panel on the left shows the binding of the T-cell receptor (TCR) to antigen and MHC proteins on the antigen-presenting cell (APC) and the binding of CD28 on the T cell to B7-1/B7-2 on the APC. It also shows the binding of B7-1/B7-2 to CTLA-4 on the T cell, which keeps the T cells in the inactive state. The panel on the right shows immune checkpoint inhibitor (anti-CTLA antibody) blocking the binding of B7-1/B7-2 to CTLA-4, which allows the T cells to be active and to kill tumor cells.
Topics/Categories: Treatment -- Immunotherapy
Type: Color, Medical Illustration (JPEG format)
Source: National Cancer Institute
Creator: Terese Winslow (Illustrator)
AV Number: CDR776560
Date Created: April 8, 2019
Date Added: May 22, 2019
Reuse Restrictions: Yes - This image is copyright protected. Any use of this image is subject to prevailing copyright laws. U.S. Government has reuse rights. Please contact the rights holder of this image for permission requests.

Rights holder: Terese Winslow