Immunohistochemical Tumor Testing For MMR Proteins

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Title: Immunohistochemical Tumor Testing For MMR Proteins
Description: Protein stains of normal and colorectal tumor tissue are shown for a single patient. The stains from the tumor (in four insets) show the presence of MSH2 and MSH6 (the dark stain is visible) and absence of MLH1 and PMS2 (the dark stain is not visible).

Immunohistochemical tumor testing for protein expression of the MMR genes associated with Lynch syndrome, depicted for a single patient with colorectal cancer. Protein expression is preserved for MSH2 and MSH6 (inset) and absent for MLH1 and PMS2 (inset). Absence of MMR protein expression is suggestive of Lynch syndrome and warrants additional evaluation.
Topics/Categories: Cancer Types -- Colorectal Cancer
Test or Procedure -- Lab Tests
Type: Color, Medical Illustration (JPEG format)
Source: National Cancer Institute
Creator: Fay Kastrinos, MD, MPH, Herbert Irving Comprehensive Cancer Center and New York-Presbyterian Hospital/Columbia University Medical Center (Illustrator)
AV Number: CDR789558
Date Created: June 21, 2017
Date Added: July 24, 2017
Reuse Restrictions: None - This image is in the public domain and can be freely reused. Please credit the source and, where possible, the creator listed above.