| Title: |
RNA Nanotechnology Enhanced Via RNA Aptamer-based Receptor Targeting |
| Description: |
The NIH Cancer Nanotechnology Platform Partnership Program at the University of Kentucky focuses on developing RNA nanotechnology for advanced cancer therapeutics. A variety of RNA nanoparticles, of which both the scaffold and therapeutic reagents are RNA molecules, have been created. This image shows ultra-stable RNA nanoparticles (red color) that have resourceful functionalities. They can self-assemble from RNA fragments carrying therapeutic RNAs and receptor targeting RNA aptamers. Systemic injection revealed that the nanoparticles specifically target to cancer cells (Green: cytoskeleton. Red: Fluorescent pRNA nanoparticle. Blue: Nuclei.) without entering healthy tissue or accumulating in normal organs (Nature Nanotechnology 2011, 6:658; Nano Today 2012, 7:245, Nature Protocols 2013, 8:1635).
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| Topics/Categories: |
Science and Technology -- Nanotechnology |
| Type: |
Color, Photo (JPEG format) |
| Source: |
National Cancer Institute |
| Creator: |
Peixuan Guo, Yi Shu, Ph.D., and Zhengyi Zhao |
| Date Created: |
May 1, 2014 |
| Date Added: |
July 21, 2016 |
| Reuse Restrictions: |
None - This image is in the public domain and can be freely reused. Please credit the source and, where possible, the creator listed above.
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