RNA Nanotechnology Enhanced Via RNA Aptamer-based Receptor Targeting
|Title:||RNA Nanotechnology Enhanced Via RNA Aptamer-based Receptor Targeting|
The NIH Cancer Nanotechnology Platform Partnership Program at the University of Kentucky focuses on developing RNA nanotechnology for advanced cancer therapeutics. A variety of RNA nanoparticles, of which both the scaffold and therapeutic reagents are RNA molecules, have been created. This image shows ultra-stable RNA nanoparticles (red color) that have resourceful functionalities. They can self-assemble from RNA fragments carrying therapeutic RNAs and receptor targeting RNA aptamers. Systemic injection revealed that the nanoparticles specifically target to cancer cells (Green: cytoskeleton. Red: Fluorescent pRNA nanoparticle. Blue: Nuclei.) without entering healthy tissue or accumulating in normal organs (Nature Nanotechnology 2011, 6:658; Nano Today 2012, 7:245, Nature Protocols 2013, 8:1635).
This image is part of the Nanotechnology Image Library collection.
|Topics/Categories:||Science and Technology -- Nanotechnology|
|Source:||National Cancer Institute|
|Creator:||Peixuan Guo, Yi Shu, Ph.D., and Zhengyi Zhao|
|Date Created:||May 1, 2014|
|Date Added:||July 21, 2016|
|Reuse Restrictions:||None - This image is in the public domain and can be freely reused. Please credit the source and, where possible, the creator listed above.|