Mouse Mammary Carcinoma

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Title: Mouse Mammary Carcinoma
Description: A cross-sectional view of a carcinoma spontaneously developed in the mammary gland of a genetically engineered mouse model. These mice have been engineered to express genetic mutations similar to women with BRCA1 mutations. Genetically engineered mice models allow us to recapitulate the environment in which these cancers develop in. Thus, we can treat them with investigational drugs, explore mechanisms and pathways influenced by treatment, as well as learn more about the cancers themselves. The cross section of carcinoma shown here was stained with hematoxylin and eosin to distinguish structural features. Hemotoxylin stains blue and binds to negative regions such as the nucleus containing DNA while eosin stains red and binds to positive regions such as proteins in the stroma.

This image was originally submitted as part of the 2016 NCI Cancer Close Up project.

This image is part of the NCI Cancer Close Up 2016 collection.

See also visualsonline.cancer.gov/closeup2016.
Topics/Categories: Cancer Types -- Breast Cancer
Cells or Tissue -- Abnormal Cells or Tissue
Type: Color, Photo (JPEG format)
Source: National Cancer Institute \ Georgetown Lombardi Comprehensive Cancer Center
Creator: Sahar Alothman, Weisheng Wang, Priscilla A. Furth
Date Created: September 2015
Date Added: April 11, 2016
Reuse Restrictions: None - This image is in the public domain and can be freely reused. Please credit the source and, where possible, the creator listed above.