Vascular Invasion by Cancer Cells

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Title: Vascular Invasion by Cancer Cells
Description: Zebrafish are a useful animal model in which to study the characteristics and behavior of human cancer cells. Here, a variety of human cell lines (labeled in red) were injected in zebrafish embryos: normal human cells (breast cells 1 and 2); human tumor cells (adenoid cystic carcinoma of salivary gland, or ACC); non-metastatic tumor cells (MCF7, ACC PDX, and MDA-MB231). The metastatic tumor cells, but not normal or non-metastatic tumor cells, exhibit vascular invasion in zebrafish within 5-7 days post injection. The animals' vascular system is labeled green; white arrows indicate site of human cell injection; red arrows indicate the invasion of tumor cells; and red arrows point to the cells that have extravasated.

This image was originally submitted as part of the 2016 NCI Cancer Close Up project.

This image is part of the NCI Cancer Close Up 2016 collection.

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Topics/Categories: Cells or Tissue -- Abnormal Cells or Tissue
Type: Color, Photo (JPEG format)
Source: National Cancer Institute \ Georgetown Lombardi Comprehensive Cancer Center
Creator: Seema Agarwal
Date Created: 2015
Date Added: April 11, 2016
Reuse Restrictions: None - This image is in the public domain and can be freely reused. Please credit the source and, where possible, the creator listed above.