Human Ectocervical Cells

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Title: Human Ectocervical Cells
Description: Infection with certain types of human papillomavirus (HPV) is associated with various cancers, including cervical cancer. Researchers are working to understand the processes by which HPV can transform a healthy cell into a cancerous one. This image shows human ectocervical cells (HEC) expressing HPV-16 E5, and immortalized with HPV-16 E6 and E7 oncoproteins. Formation of koilocytes requires cooperation between HPV E5 and E6 oncoproteins. E5 localizes to perinuclear vesicles in koilocytotic cells. The cell culture is stained with hematoxylin (blue) and reacted with antibody against epitope-tagged E5 (brown) .

This image was originally submitted as part of the 2016 NCI Cancer Close Up project.
Topics/Categories: Cancer Types -- Cervical Cancer
Cells or Tissue -- Abnormal Cells or Tissue
Type: Color, Photo (JPEG format)
Source: National Cancer Institute \ Georgetown Lombardi Comprehensive Cancer Center
Creator: Ewa Krawczyk
Date Created: 2008
Date Added: April 11, 2016
Reuse Restrictions: None - This image is in the public domain and can be freely reused. Please credit the source and, where possible, the creator listed above.