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As tumors grow, they outpace the surrounding blood vessels' ability to provide enough oxygen, a state known as hypoxia. Rather than killing the tumor, however, hypoxia triggers changes in cancer cell metabolism that actually promote tumor growth and spread. Understanding more about hypoxia in cancer cells may help researchers find better ways of managing the disease. This image of a mouse model for HER2-positive breast cancer uses a novel imaging technique called transparent tumor tomography that three-dimensionally visualizes the tumor microenvironment at a single cell resolution. Hypoxic areas are in green; HER2 proteins in blue; CD31 endothelial cells in red.
This image was originally submitted as part of the 2016 NCI Cancer Close Up project.
This image is part of the NCI Cancer Close Up 2016 collection.
See also https://visualsonline.cancer.gov/closeup2016.
Cancer Types -- Breast Cancer
Cells or Tissue -- Abnormal Cells or Tissue
|Source:||National Cancer Institute \ Univ. of Chicago Comprehensive Cancer Center|
|Creator:||Steve Seung-Young Lee|
|Date Created:||August 2015|
|Date Added:||April 11, 2016|
|Reuse Restrictions:||None - This image is in the public domain and can be freely reused. Please credit the source and, where possible, the creator listed above.|