Cancer to Bone

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Title: Cancer to Bone
Description: When cancer cells metastasize to the bone microenvironment from the primary site, they secrete factors that stimulate osteoclasts both to resorb mineralized bone matrix and release stored growth factors that further enhance the growth of cancer cells. Knowing how cancer cells spread to bone and cause bone destruction is important to finding successful treatment. This image shows a large multinucleated osteoclast (red) resorbing bone matrix (orange) adjacent to cancer cells (purple).

This image was originally submitted as part of the 2016 NCI Cancer Close Up project and selected for exhibit.

This image is part of the NCI Cancer Close Up 2016 collection.

See also https://visualsonline.cancer.gov/closeup2016.
Topics/Categories: Cancer Types -- Bone Cancer
Cells or Tissue -- Abnormal Cells or Tissue
Type: Color, Photo
Source: National Cancer Institute \ Indiana Univ. Simon Cancer Center
Creator: Khalid Mohammad and Theresa Guise
Date Created: January 2016
Date Added: April 11, 2016
Reuse Restrictions: None - This image is in the public domain and can be freely reused. Please credit the source and, where possible, the creator listed above.