Treatment-Resistant Breast Cancer Cells

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Title: Treatment-Resistant Breast Cancer Cells
Description: Human tumors often include slowly proliferating cancer cells that resist treatment. This image shows a cluster of slow-cycling (AKT-low/Hes1-high) breast cancer cells (red) within a human ER+ primary breast tumor (cell nuclei in blue; rapidly cycling, AKT-high, cancer cells in green). Cancer cells enter an AKT-low state in response to decreased interaction of cell surface beta-1 integrin with the extracellular matrix. AKT-low cancer cells within invasive breast cancer tumors persist after combination chemotherapy and contribute to tumor progression.

This image was originally submitted as part of the 2016 NCI Cancer Close Up project.

This image is part of the NCI Cancer Close Up 2016 collection.

See also https://visualsonline.cancer.gov/closeup2016.
Topics/Categories: Cancer Types -- Breast Cancer
Cells or Tissue -- Abnormal Cells or Tissue
Type: Color, Photo
Source: National Cancer Institute \ Dana-Farber Harvard Cancer Center at Massachusetts General Hospital
Creator: Sheheryar Kabraji, Sridhar Ramaswamy
Date Created: January 2016
Date Added: April 11, 2016
Reuse Restrictions: None - This image is in the public domain and can be freely reused. Please credit the source and, where possible, the creator listed above.