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A high level of the critical gene Sox10 is tied to aggressive breast cancer. In parts of the adult mammary gland, Sox10 is expressed in cells with higher levels of stem cell activity and not in mature cells that lack detectable stem cell activity. Progesterone receptor (red) indicates non-stem-like mammary cells, which show an inverse correlation with cells expressing Sox10 (blue). A protein called cytokeratin-8 (green) shows the development of the gland.
This image was originally submitted as part of the 2016 NCI Cancer Close Up project.
This image is part of the NCI Cancer Close Up 2016 collection.
See also visualsonline.cancer.gov/closeup2016.
Cancer Types -- Breast Cancer
Cells or Tissue -- Abnormal Cells or Tissue
|Type:||Color, Photo (JPEG format)|
|Source:||National Cancer Institute \ Salk Institute|
|Creator:||Geoffrey Wahl, Christopher Dravis|
|Date Created:||September 2015|
|Date Added:||April 11, 2016|
|Reuse Restrictions:||None - This image is in the public domain and can be freely reused. Please credit the source and, where possible, the creator listed above.|