Cryo-Electron Microscopy

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Title: Cryo-Electron Microscopy
Description: It is possible to use an imaging technique called cryo-electron microscopy (cryo-EM) to view, in atomic detail, the binding of a potential small molecule drug to a key protein in cancer cells. The cryo-EM image shown here helped researchers establish the sequence of structural changes that normally occur in the protein, p97. The protein p97, an important target for cancer therapies, is trapped in an inactive state by a new inhibitor. With the inhibitor (red) in place, the molecule cannot proceed into its normal reaction cycle, illustrated schematically along the circular gauge.

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Topics/Categories: Science and Technology -- Laboratory Techniques/Equipment
Type: Color, Illustration (JPEG format)
Source: National Cancer Institute (NCI)
Creator: Veronica Falconieri, Sriram Subramaniam
Date Created: December 2015
Date Added: January 28, 2016
Reuse Restrictions: None - This image is in the public domain and can be freely reused. Please credit the source and, where possible, the creator listed above.