About a third of all human cancers, including a high percentage of pancreatic, lung, and colorectal cancers, are driven by mutations in RAS genes. When Ras genes are mutated, cells grow uncontrollably and evade death signals. Ras mutations also make cells resistant to some therapies. Many of these effects occur as a result of Ras-induced changes in mitochondrial shape. This image shows mitochondrial staining (green) and nuclear staining (blue) following inhibition of the mitochondrial fission machinery in human epithelial cells engineered to express oncogenic Ras.
This image was originally submitted as part of the 2016 NCI Cancer Close Up project.
This image is part of the NCI Cancer Close Up 2016 collection.
See also https://visualsonline.cancer.gov/closeup2016.
Cells or Tissue -- Abnormal Cells or Tissue
Science and Technology -- Genetics
|Source:||National Cancer Institute / Univ. of Virginia Cancer Center|
|Date Created:||January 2015|
|Date Added:||April 11, 2016|
|Reuse Restrictions:||None - This image is in the public domain and can be freely reused. Please credit the source and, where possible, the creator listed above.|