Vascular Invasion by Cancer Cells

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Title: Vascular Invasion by Cancer Cells
Description: Zebrafish are a useful animal model in which to study the characteristics and behavior of human cancer cells. Here, a variety of human cell lines (labeled in red) were injected in zebrafish embryos: normal human cells (breast cells 1 and 2); human tumor cells (adenoid cystic carcinoma of salivary gland, or ACC); non-metastatic tumor cells (MCF7, ACC PDX, and MDA-MB231). The metastatic tumor cells, but not normal or non-metastatic tumor cells, exhibit vascular invasion in zebrafish within 5-7 days post injection. The animals' vascular system is labeled green; white arrows indicate site of human cell injection; red arrows indicate the invasion of tumor cells; and red arrows point to the cells that have extravasated.

This image was originally submitted as part of the 2016 NCI Cancer Close Up project.
Topics/Categories: Cells or Tissue -- Abnormal Cells or Tissue
Type: Color, Photo (JPEG format)
Source: National Cancer Institute \ Georgetown Lombardi Comprehensive Cancer Center
Creator: Seema Agarwal
Date Created: 2015
Date Added: April 11, 2016
Reuse Restrictions: None - This image is in the public domain and can be freely reused. Please credit the source and, where possible, the creator listed above.