Breast Tumor Microenvironment

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Title: Breast Tumor Microenvironment
Description: This image of a breast cancer tumor and its microenvironment was obtained from a live mouse model using multiphoton microscopy and endogenous fluorescence. That is, the image was obtained without any fluorophores, stains, or dyes, using only the metabolic co-factors of NADH and FAD, which are already inside of cells, along with second harmonic generation to see collagen. This technique has important clinical potential for patients who require label-free imaging, and may lead to more effective diagnoses and treatments. Tumor cells display in cyan, macrophages in red, collagen fibers in green.

This image was originally submitted as part of the 2016 NCI Cancer Close Up project and selected for exhibit.
Topics/Categories: Cancer Types -- Breast Cancer
Cells or Tissue -- Abnormal Cells or Tissue
Type: Color, Photo (JPEG format)
Source: National Cancer Institute \ Carbone Cancer Center at the Univ. of Wisconsin
Creator: Joseph Szulczewski, David Inman, Kevin Eliceiri, and Patricia Keely
Date Created: January 2016
Date Added: April 11, 2016
Reuse Restrictions: None - This image is in the public domain and can be freely reused. Please credit the source and, where possible, the creator listed above.