Focal Adhesions in Breast Cancer

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Title: Focal Adhesions in Breast Cancer
Description: Some breast cancers overexpress a type of enzyme called Nek3, which plays a role in how a cell organizes itself and moves throughout the body. This image shows breast cancer cells overexpressing the enzyme Nek3 (red), revealing marked enlargement of focal adhesions and associated proteins such as paxillin (pink) that help the cell's cytoskeleton (actin, in green) connect to surrounding tissues. This research provides the rationale for a targeted therapy against Nek3. Nuclear DNA is pictured in in blue.

This image was originally submitted as part of the 2016 NCI Cancer Close Up project and selected for exhibit.
Topics/Categories: Cancer Types -- Breast Cancer
Cells or Tissue -- Abnormal Cells or Tissue
Type: Color, Photo (JPEG format)
Source: National Cancer Institute \ Massey Cancer Center at Virginia Commonwealth Univ.
Creator: Charles V. Clevenger, Katherine Harrington
Date Created: December 2015
Date Added: April 11, 2016
Reuse Restrictions: None - This image is in the public domain and can be freely reused. Please credit the source and, where possible, the creator listed above.