Spheroids Cultured Under Hypoxia

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Title: Spheroids Cultured Under Hypoxia
Description: This image shows a cultured tumor spheroid in a state of hypoxia under 1 percent oxygen. Hypoxic areas of the spheroid are marked in green, with nuclear DIPA co-staining (blue). As tumors grow, they outpace the surrounding blood vessels' ability to provide enough oxygen, a state known as hypoxia. Rather than killing the tumor, however, hypoxia somehow triggers changes in cancer cell metabolism that allow for the tumor's continuous growth and spread into nearby tissues. Understanding more about hypoxia in cancer cells may help researchers find better ways of managing the disease.

This image was originally submitted as part of the 2016 NCI Cancer Close Up project.
Topics/Categories: Cells or Tissue -- Abnormal Cells or Tissue
Type: Color, Photo (JPEG format)
Source: National Cancer Institute \ Simmons Comprehensive Cancer Center at the Univ. of Texas
Creator: Lei Jiang
Date Created: August 2013
Date Added: April 11, 2016
Reuse Restrictions: None - This image is in the public domain and can be freely reused. Please credit the source and, where possible, the creator listed above.