Self-Driven Probiotic-CRISPR/Cas9 Nanosystem for Sono-Immunometabolic Cancer Therapy
| Title: | Self-Driven Probiotic-CRISPR/Cas9 Nanosystem for Sono-Immunometabolic Cancer Therapy |
|---|---|
| Description: |
Elemental mapping of Transmission electron microscopy (TEM) images of probiotic-CRISPR/Cas9 nanosystem consisting of a Lactobacillus rhamnosus GG (LGG) self-driven multifunctional delivery vector constructed to efficiently deliver the CRISPR-Cas9 nanosystem for indoleamine 2,3-dioxygenase-1 (IDO1) knockdown in order to amplify immunogenic cell death (ICD) and then reverse tumor immunosuppression in lung metastasis. Source: Yu J, Zhou B, Zhang S, Yin H, Sun L, Pu Y, Zhou B, Sun Y, Li X, Fang Y, Wang L, Zhao C, Du D, Zhang Y, Xu H. Design of a self-driven probiotic-CRISPR/Cas9 nanosystem for sono-immunometabolic cancer therapy. Nat Commun. 2022 Dec 22;13(1):7903. doi: 10.1038/s41467-022-35580-z. PMID: 36550159; PMCID: PMC9780327. See also www.ncbi.nlm.nih.gov/pmc/articles/PMC9780327/. |
| Topics/Categories: | Science and Technology -- Nanotechnology |
| Type: | Color, Photo (JPEG format) |
| Source: | National Cancer Institute (NCI) |
| Date Created: | Unknown |
| Date Added: | November 15, 2023 |
| Reuse Restrictions: | None - This image is in the public domain and can be freely reused. Please credit the source and, where possible, the creator listed above. |