Coupling Nanostructured Microchips with Covalent Chemistry for Purification of Sarcoma-Derived Extracellular Vesicles for Downstream Functional Studies
| Title: | Coupling Nanostructured Microchips with Covalent Chemistry for Purification of Sarcoma-Derived Extracellular Vesicles for Downstream Functional Studies |
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| Description: |
Silicon (Si) nanowire chips (left) can be used to capture rare cells from blood samples to diagnose diseases early. On the right, scanning electron microscopy (SEM) images display extracellular vesicles (EVs) captured on the tips of Si nanowire arrays and the sidewalls of Si nanowires. These tumor-derived EVs play essential role in inter-cellular communication during tumor growth and metastatic evolution. In this study, Ewing sarcoma (ES)-derived EVs were captured on nanowire chip. The cells can also be released from the chip for further analysis. Source: Dong J, Zhang RY, Sun N, Hu J, Smalley MD, Zhou A, Yue H, Rothermich W, Chen M, Chen J, Ye J, Teng PC, Qi D, Toretsky JA, Tomlinson JS, Li M, Weiss PS, Jonas SJ, Federman N, Wu L, Zhao M, Tseng HR, Zhu Y. Coupling Nanostructured Microchips with Covalent Chemistry Enables Purification of Sarcoma-Derived Extracellular Vesicles for Downstream Functional Studies. Adv Funct Mater. 2020 Dec 1;30(49):2003237. doi: 10.1002/adfm.202003237. Epub 2020 Sep 13. PMID: 34220409; PMCID: PMC8248519. See also www.ncbi.nlm.nih.gov/pmc/articles/PMC8248519/. |
| Topics/Categories: | Science and Technology -- Nanotechnology |
| Type: | Color, Photo (JPEG format) |
| Source: | National Cancer Institute (NCI) |
| Date Created: | Unknown |
| Date Added: | November 15, 2023 |
| Reuse Restrictions: | None - This image is in the public domain and can be freely reused. Please credit the source and, where possible, the creator listed above. |